Sex as a Biological Variant (SABV)

SABV

Data continues to accumulate and suggest that women and men have different risks for the onset, expression, course, treatment, and outcomes across the lifespan. Understanding the mechanisms that underly and explain these sex differences is still unclear and will require translational models of investigating these sex differences, the vulnerabilities across the lifespan and ultimately developing operational research that addresses issues related to women’s health, treatment, and health care. The SABV policy requires that all research factor sex into the design, analysis, and reporting of both vertebrate and human studies.

Cardiovascular disease continues to be the number one killer of women in the United States and affects women and men differently, in prevalence, underlying physiology, risk factors, presenting stepson and outcomes Racial and ethnic disparities occur with black women more likely than white women to experience the disease and die from it. Despite these startling statistics, women continue to lag behind men in enrolling in important clinical trials, trials that could shape and reduce these disparities.

Relevant articles that the Center, our trainees, and partners have published in this area: